Chapter 2 Tamoxifen
نویسنده
چکیده
Tamoxifen (ICI 46,474), the trans isomer of a substituted triphenylethylene, was discovered in the fertility program at Imperial Chemical Industries, Pharmaceuticals Division, Cheshire, England. The plan was to use tamoxifen to regulate fertility, but this failed and interest refocused outside the company for applications to treat breast cancer. The initial application of the nonsteroidal antiestrogen was for the treatment of metastatic breast cancer in postmenopausal women and by the 1980s tamoxifen had replaced high-dose diethylstilbestrol therapy. Efficacy when compared with diethylstilbestrol was similar, but tamoxifen had fewer side effects. No other antiestrogenswere developed by the pharmaceutical industry, as this was not considered a financially lucrative development strategy.
منابع مشابه
Chapter 2 Tamoxifen Goes Forward Alone
Tamoxifen (ICI 46,474), the trans isomer of a substituted triphenylethylene, was discovered in the fertility program at Imperial Chemical Industries, Pharmaceuticals Division, Cheshire, England. The plan was to use tamoxifen to regulate fertility, but this failed and interest refocused outside the company for applications to treat breast cancer. The initial application of the nonsteroidal antie...
متن کاملNano packaged Tamoxifen and Curcumin; effective formulation against sensitive and resistant MCF-7 cells
Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...
متن کاملEffects of Tamoxifen on Morphological and Ultrastructural Aspects of Developing Hippocampus of Rat
Background: Tamoxifen treatment induced cell death in the hippocampus formation of the prenatal and postnatal rat. The present study delineates the effect of tamoxifen on developing hippocampus in prenatal, postnatal and full term neonate rats received certain doses of the partial antagonist tamoxifen. Methods: After perfusion and fixation, the brains were removed and processed for light and e...
متن کاملمقایسه اثرات تاموکسیفن در بروز سنگهای صفراوی در بیماران زن مبتلا به کانسر پستان
Background & Aims: Tamoxifen is used in breast cancer as adjuvant hormonal therapy. Some studies have found effect of tamoxifen on bile components and gallstone formation. The purpose of the study was to find out the association between tamoxifen use in patient with breast cancer and gallstone formation. Materials & Methods: 780 patient with breast cancer who had undergone surgery in 3 hospita...
متن کاملThe Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines
It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
متن کامل